发明名称 |
Mutated env sequence involved in the modulation of the immunosuppressive effect of viral proteins |
摘要 |
Mutated viral ENV proteins having mutations in the immunosuppressive domain (ISU) of the transmembrane subunit (TM) have decreased immunosuppressive activity with respect to the wild-type ENV protein. Pharmaceutical compositions that include the protein and nucleic acids coding for the protein are also disclosed. |
申请公布号 |
US8597657(B2) |
申请公布日期 |
2013.12.03 |
申请号 |
US201213399208 |
申请日期 |
2012.02.17 |
申请人 |
RENARD MARTIAL;MANGENEY MARIANNE;HEIDMANN THIERRY;INSTITUT GUSTAVE ROUSSY;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSITE PARIS SUD XI |
发明人 |
RENARD MARTIAL;MANGENEY MARIANNE;HEIDMANN THIERRY |
分类号 |
A61K39/21;A61K38/00;A61K38/08;A61K38/10;A61K39/00;C07K7/06;C07K7/08;C12N5/00;C12N7/00;C12N7/04;C12N15/63;C12N15/86 |
主分类号 |
A61K39/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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