发明名称 |
Composiciones antiincrustantes, antimicrobianas y antitrombogénicas de injerto desde la superficie |
摘要 |
Substrates, optionally coated with an undercoating layer, having grafted there from one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted from a variety of substrate materials, particularly polymeric substrates and/or polymeric undercoating layers. The graft-from techniques described herein can result in higher surface densities of the non-fouling material relative to graft-to formulations. Graft-from methods can be used to produce covalently tethered polymers. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted from the substrate, or optionally from an undercoating layer on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.
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申请公布号 |
ES2432388(T3) |
申请公布日期 |
2013.12.03 |
申请号 |
ES20090796517T |
申请日期 |
2009.12.07 |
申请人 |
SEMPRUS BIOSCIENCES CORPORATION |
发明人 |
LI, JUN;SQUIER, TREVOR;ZHANG, ZHENG;O'SHAUGHNESSEY, WILLIAM SHANNAN;HENCKE, MICHAEL;BOUCHARD, MICHAEL;LOOSE, CHRISTOPHER R.;HUVAL, CHAD |
分类号 |
A61L27/50;A61L33/06;C08F265/04;C08F283/00;C08F291/18 |
主分类号 |
A61L27/50 |
代理机构 |
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代理人 |
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地址 |
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