发明名称 |
Compressed solid dosage form manufacturing process well-suited for use with drugs of low aqueous solubility and compressed solid dosage forms made thereby |
摘要 |
A pharmaceutical formulation of compounds with low aqueous solubility and method of manufacture thereof. The formulation may include a pharmacologically active compound having low aqueous solubility and starch in the amount of greater than about 25 weight percent. A manufacturing method may include blending the active compound and starch, compressing the blend into a solid, comminuting the solid into granules, wetting the granules, drying the granules, and tabletting the dried granules to make a solid pharmaceutical formulation. |
申请公布号 |
US8597666(B2) |
申请公布日期 |
2013.12.03 |
申请号 |
US201113284454 |
申请日期 |
2011.10.28 |
申请人 |
ZALIT ILAN;LESKA FANNY;KADOSH MALI;MARCO DORIT;MESSER-TRIGER YONIT;TEVA PHARMACEUTICAL INDUSTRIES, LTD. |
发明人 |
ZALIT ILAN;LESKA FANNY;KADOSH MALI;MARCO DORIT;MESSER-TRIGER YONIT |
分类号 |
A61K9/00;A61K9/20;A61K9/64;A61K31/40;A61K31/445;A61K31/55 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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