| 摘要 |
The present invention relates to a chitosan-graft-(polypeptide-poly(ethylene glycol)) (CS-g-(PP-PEG)) having a molecular weight of between 5,000 and 2,000,000 Daltons, which is obtained through a reaction between chitosan and a poly(ethylene glycol)/poly(peptide) block copolymer having a molecular weight of between 1,000 and 50,000 Daltons comprising poly(ethylene glycol) having a molecular weight of between 500 and 5,000 Daltons and a hydrophobic poly(peptide) having a molecular weight of between 300 and 10,000 Daltons. A feature of this macromolecular aqueous solution is that, at above a predetermined concentration, the sol-gel transition temperature can be adjusted in accordance with the pH and the temperature, and the aim is use in medicinal product delivery systems, three-dimensional cell culturing and tissue engineering. |
