发明名称 |
USE OF STABILIZED GRANULES CONTAINING GLYCERYL TRINITRATE FOR ARTERIOGENESIS |
摘要 |
The present invention inter alia relates to a method of treating or preventing an arterial insufficiency, wherein an NO donor is administered in an intermitting manner to a subject in an amount effective for the induction of arteriogenesis, and wherein the NO donor is a solid pharmaceutical preparation with the active substance glyceryl trinitrate for oromucosal or oral administration characterized in that it contains between 0.05 and 2 weight% glyceryl trinitrate (GTN), at least one diluent, one carrier material, and at least one substance that reduces the volatility of GTN, whereby this substance is a non-volatile ester stabilizer whose melting point is not higher than 60 °C. |
申请公布号 |
CA2778679(A1) |
申请公布日期 |
2013.11.30 |
申请号 |
CA20122778679 |
申请日期 |
2012.05.31 |
申请人 |
G. POHL-BOSKAMP GMBH & CO. KG |
发明人 |
GORATH, MICHAELA;PAESCHKE, ROBERT |
分类号 |
A61K9/00;A61K31/04;A61K47/14;A61P9/10 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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