AMINOPYRIMIDINES AS SYK INHIBITORS

摘要

600673 Disclosed herein is a compound of formula (I), wherein the variables are defined in the specification, and the use thereof in the treatment of a SYK-mediated disease. Specific embodiments of the compound include: (1R,4S)-4-[5-(3-cyclopropyl-5-{ [4-(trifluoromethyl)pyrimidin-2-yl]amino} phenyl)-1,3-thiazol-2-yl]-4-hydroxy-2,2-dimethylcyclohexanecarboxylic acid; (1S,4R)-4-hydroxy-2,2-dimethyl-4-[5-(3-methyl-5-{ [4-(propan-2-yloxy)pyrimidin-2-yl]amino} phenyl)-1,3-thiazol-2-yl]cyclohexanecarboxamide; and (1S,4R)-4-hydroxy-2,2-dimethyl-4-[5-(3-methyl-5-{ [4-(trifluoromethyl)pyrimidin-2-yl]amino} phenyl)-1,3-thiazol-2-yl]cyclohexanecarboxylic acid;