发明名称 REDUCTIVE AMINATION PROCESS FOR PREPARATION OF DRONEDARONE USING AMINE INTERMEDIARY COMPOUND
摘要 <p>The invention relates to a novel process for preparation of drohedarone of formula (I) and pharmaceutically acceptable salts thereof characterized in that a compound of formula (II) is reacted in the presence of a reductive agent with butyraldehyde and/or butanoic acid, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. The invention also relates to some hovel intermediary compounds and the preparation thereof.</p>
申请公布号 SG194021(A1) 申请公布日期 2013.11.29
申请号 SG20130073341 申请日期 2012.03.27
申请人 SANOFI 发明人 FRIESZ, ANTAL;HUSZAR, CSABA
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