IMPROVED ANTI-SERUM ALBUMIN BINDING VARIANTS

摘要

595242 Disclosed is an anti-serum albumin (SA) immunoglobulin single variable domain variant of DOM7h-11, wherein the variant comprises at least one mutation in the FW2/CD2 junction, wherein: Position 49 is Leu; or Position 50 is Ala or Trp; or Position 51 is Phe or Asn; And wherein the variant has from 2 to 8 changes compared to the amino acid sequence of DOM7h-11.