DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF

摘要

596711 Discloses a dual binding antibody comprising a first and second polypeptide chains, each independently comprising VD1-(X1)n-VD2-C-(X2)n, Wherein the first polypeptide chain forms binding sites for EGFR and the second polypeptide forms binding sites for CD3, IGF1R, RON, HGF, VEGF, Erb33, DLL-4, PLGF, EGFR, RGMA and Tetanus toxoid proteins. Further discloses the use of the protein in the manufacture of a medicament for treating a disease or disorder.