IMMEDIATE RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING OXYCODONE AND NALOXONE

摘要

595663 Disclosed herein is an oral immediate release pharmaceutical composition comprising at least oxycodone or a pharmaceutically acceptable salt thereof and naloxone or a pharmaceutically acceptable salt thereof in about a 2:1 ratio (oxycodone or a pharmaceutically acceptable salt thereof: naloxone or a pharmaceutically acceptable salt thereof) by weight, wherein the formulation releases in vitro, when measured using the Ph. Eur. Paddle Method at 100 rpm in 0.1 N hydrochloric acid at 37°C and using UV detection at 230 nm, > 75% of oxycodone or a pharmaceutically acceptable salt thereof by weight and > 75 % of naloxone or a pharmaceutically acceptable salt thereof by weight at 45 min, and the use thereof in the treatment of pain.