ANTHELMINTIC AGENTS AND THEIR USE

摘要

594765 Disclosed herein is a compound of formula I, wherein the variables are defined in the specification; use thereof as anthelmintic agents in the treatment of a parasitic infection; and a pharmaceutical composition comprising said compound. Examples of the compound include the following: 2-trifluoromethyl-4-(1-{ 4-[4-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)-piperazin-1-yl]-butyryl} -piperidin-4-ylamino)benzonitrile, 4-[4-(4-tert-butyl-phenyl)-piperazin-1-yl]-1-[(R)-3-(4-nitro-3-trifluoromethyl-phenylamino)-pyrrolidin-1-yl]-butan-1-one, and 3-[1-(4-tert-butyl-phenyl)-piperidin-4-yl]-1-[4-(4-nitro-3-trifluoromethyl-phenylamino)-piperidin-1-yl]-propan-1-one.