发明名称 |
PYRIDAZINE DERIVATIVES AS SMO INHIBITORS |
摘要 |
<p>The present invention relates to compounds of formula I: in which R11 and R12 are defined in the Summary of the Invention; capable of inhibiting the Hedgehog and Smo signaling pathway. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the diagnosis and treatment of pathologies relating to the Hedgehog and Smo signaling pathway, for example, tumor formation, cancer, neoplasia and non-malignant hyperproliferative disorders.</p> |
申请公布号 |
HK1155736(A1) |
申请公布日期 |
2013.11.29 |
申请号 |
HK20110109939 |
申请日期 |
2011.09.21 |
申请人 |
NOVARTIS AG |
发明人 |
HE, FENG;PEUKERT, STEFAN;MILLER-MOSLIN, KAREN;YUSUFF, NAEEM;CHEN, ZHUOLIANG;LAGU, BHARAT |
分类号 |
C07D;A61K;A61P |
主分类号 |
C07D |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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