NOVEL PROTEIN AND USE THEREOF

摘要

The present invention relates to: a novel protein; a biosensor comprising the same; a method for preparing the biosensor; an immunoassay method using the biosensor; a column for separating and purifying a specific antigen in which an antibody is bound to a silica-containing solid phase to which the protein is bound; a separation and purification method using the column; and an in vivo drug delivery vehicle. The present invention provides a method for adhering an antibody to silica with remarkable biocompatibility by utilizing a protein comprising an N-terminal having a high binding force to silica and a C-terminal having a binding force to an Fc region of an antibody. If the protein is used as a linker, an adhered antibody can have proper orientation, thereby enabling high antibody detection sensitivity as a biosensor. In addition, since an antibody for various antigens can be bound to a silica-containing solid phase through the protein, the present invention can be used for a biosensor, an immunoassay method, separation or purification, target-specific drug delivery and target-specific imaging with respect to various antigens of which the antibodies exist and can be applied in a very wide field.