| 摘要 |
A method of synthesizing cycloalkanyl [b] indoles, as well as related cycloalkanyl [b] benzofurans and cycloalkanyl [b] benzothiophenes is provided. The method is a single, multicomponent reaction that combines (1) an indole, benzofuran, or benzothiopene, (2) an aldehyde, ketone, or ketal, and (3) a diene in the presence of an acid, in particular a Ga(III) or In (III) salt. Compositions and methods of using these compounds to stimulate secretion and/or production of glucagon-like peptide-l or inhibit the activity of Calcitonin Gene-Related Peptide receptor are also provided. |
