发明名称 |
Neuroprotection and myelin repair using nestorone® |
摘要 |
Methods for treating neurodegeneration and/or myelination in patients are disclosed comprising treating the patient with a progestin compound which exerts binding to progesterone receptors and elicits progesterone-receptor-induced biological responses without interacting with the androgen receptor and without inducing androgen or glucocorticoid biological responses at a dosage sufficient to prevent or reduce neurodegeneration. The progestin compound preferably comprises 16-methylene-17α-acetoxy-19-norpregn-4-ene-3, 20-dione, and the methods include combining the progestin compound with an estrogen compound to provide both contraception and treatment for myelin repair and neurodegeneration. |
申请公布号 |
AU2010308308(B2) |
申请公布日期 |
2013.11.28 |
申请号 |
AU20100308308 |
申请日期 |
2010.10.19 |
申请人 |
THE POPULATION COUNCIL, INC. |
发明人 |
SITRUK-WARE, REGINE;SCHUMACHER, MICHAEL MARIA HELMUT;BRINTON, ROBERTA;EL-ETR, MARTINE;GHOUMARI, ABDELMOUMAN;GUENNOUN, RACHIDA |
分类号 |
A61K31/00;A61K31/565;A61K31/57;A61K31/573;A61K31/575;A61K31/585;A61K45/06;A61P25/00;A61P25/16;A61P25/28 |
主分类号 |
A61K31/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|