OPTIMIZED AAV-VECTORS FOR HIGH TRANSDUCTION RATES IN DENDRITIC CELLS

摘要

The present invention is concerned with a polynucleotide encoding an adeno-associated virus (AAV) capsid polypeptide comprising the amino acid sequence NYSRGVD or the amino acid sequence NEARVRE. The present invention further relates to an AAV capsid polypeptide encoded by said polynucleotide and the use therof as a medicament, in preventing and /or treating infectious disease, and in preventing and /or treating cancer. The invention also relates to a method of presenting at least one antigen on the surface of an antigen presenting cell (APC) and to a method for identifying a peptide mediating binding of a virus to a target cell, as well as kits and devices comprising the compounds of the invention.