3',5'-CYCLIC PHOSPHORAMIDATE PRODRUGS FOR HCV INFECTION

摘要

Provided herein are compounds of formula (I) compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. Formula (I) or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein: each X is independently alkoxyl, hydrogen, or hydroxyl; each Y is independently hydroxyl, acetoxyl, or fluoro; each Z is independently substituted alkyl; and each R is independently hydrogen, alkyl, substituted alkyl, cycloalkyl, aryl, or heteroaryl.