发明名称 |
ANTI-CCL2 ANTIBODIES FOR TREATMENT OF SCLERODERMA |
摘要 |
The present invention provides, among other things, improved anti-CCL2 antibodies characterized with high affinity, potency, tissue selectivity and/or epitope specificity, and uses thereof, in particular, for treatment of scleroderma and related fibrotic and/or inflammatory diseases, disorders and conditions. In some embodiments, the present invention provides methods and compositions for treatment of scleroderma and related fibrotic and/or inflammatory diseases, disorders and conditions based on an anti-CCL2 antibody having an affinity of 10-12 M or greater. |
申请公布号 |
WO2013177264(A1) |
申请公布日期 |
2013.11.28 |
申请号 |
WO2013US42196 |
申请日期 |
2013.05.22 |
申请人 |
SHIRE HUMAN GENETIC THERAPIES, INC. |
发明人 |
MARTINI, PAOLO, G.V.;NATARAJAN, MADHUSUDAN;HASLETT, PATRICK, ANTHONY, JOHN;SEYMOUR, ALBERT, BARNES |
分类号 |
A61K39/395;C07K16/00;C12P21/08 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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