发明名称 Method for the synthesis of anticancer (poly)aminoalkylaminoacetamide derivatives of epipodophyllotoxin
摘要 <p>The present invention describes a new process for the preparation of (poly)aminoalkylaminoacetamide compounds of epipodophyllotoxin useful for their applications in therapeutics as anticancer agents. This process comprises a step of condensation of a primary-amine-containing reactant, whose amine functions are not protected, with &bgr;-chloroacetamido-4&prime;-epipodophyllotoxin in a polar aprotic organic solvent.</p>
申请公布号 IL204636(A) 申请公布日期 2013.11.28
申请号 IL20100204636 申请日期 2010.03.21
申请人 PIERRE FABRE MEDICAMENT 发明人
分类号 C07D 主分类号 C07D
代理机构 代理人
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