ANTI-MACROPHAGE MANNOSE RECEPTOR SINGLE VARIABLE DOMAINS FOR TARGETING AND IN VIVO IMAGING OF TUMOR-ASSOCIATED MACROPHAGES
摘要
The present invention relates to immunoglobulin single variable domains directed against human macrophage mannose receptor (MMR) and their uses in the field of oncology. More specifically, it concerns immunoglobulin single variable domains, including nanobodies, against human MMR and their use in targeting and in vivo imaging of tumor-associated macrophages, with applications in the field of cancer diagnostics and therapeutics and monitoring of the disease.
申请公布号
WO2013174537(A1)
申请公布日期
2013.11.28
申请号
WO2013EP55427
申请日期
2013.03.15
申请人
VIB VZW;VRIJE UNIVERSITEIT BRUSSEL
发明人
VAN GINDERACHTER, JO;DE BAETSELIER, PATRICK;DEVOOGDT, NICK;LAHOUTTE, TONY;LAOUI, DAMYA;MOVAHEDI, KIAVASH;RAES, GEERT;SCHOONOOGHE, STEVE