发明名称 |
CARRIER FOR TARGETING NERVE CELLS |
摘要 |
The present invention relates to a transport protein which can be obtained by modifying the heavy chain of the neurotoxin formed by Clostridium botulinum wherein (i) the protein binds specifically to nerve cells with a higher or lower affinity as the native neurotoxin; (ii) the protein has an increased or reduced neurotoxicity compared to the native neurotoxin, the neurotoxicity being preferably determined in the hemidiaphragm assay; and/or (iii) the protein comprises a lower affinity against neutralizing antibodies compared to the native neurotoxin. The invention also relates to methods for producing the same and the use thereof in cosmetic and pharmaceutical compositions.
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申请公布号 |
US2013315888(A1) |
申请公布日期 |
2013.11.28 |
申请号 |
US201313867740 |
申请日期 |
2013.04.22 |
申请人 |
RUMMEL ANDREAS;WEIL TANJA;GUTCAITS ALEKSANDRS;SYNTAXIN LIMITED |
发明人 |
RUMMEL ANDREAS;WEIL TANJA;GUTCAITS ALEKSANDRS |
分类号 |
C12N9/52 |
主分类号 |
C12N9/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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