发明名称 |
HEMATOPOIETIC CELL FROM HUMAN EMBRYONIC STEM CELL |
摘要 |
PROBLEM TO BE SOLVED: To provide a system for producing cells of the hematopoietic lineage from embryonic stem cells.SOLUTION: Differentiation is conducted in the presence of hematopoietic cytokines and other factors. The cell population that is obtained is remarkably enriched in CD45 +ve cells, a marker of early hematopoietic precursor with self-renewing capacity. Including a bone morphogenic protein during the differentiation process enhances the ability of the cell population to form secondary colonies. Because of the enormous replicative capacity of embryonic stem cells, this provides an important new commercial source of hematopoietic cells. |
申请公布号 |
JP2013236636(A) |
申请公布日期 |
2013.11.28 |
申请号 |
JP20130127621 |
申请日期 |
2013.06.18 |
申请人 |
GERON CORP;ROBARTS RESEARCH INST |
发明人 |
BHATIA MICKIE;MADRENAS JOAQUIN;FERBER IRIS A;MAJUMDAR ANISH SEN |
分类号 |
C12N5/071;C12N5/10;A61K35/12;A61K48/00;A61P7/00;A61P7/06;A61P29/00;A61P35/00;A61P35/02;A61P37/02;A61P37/06;A61P43/00;C12N5/0735;C12N5/078;C12Q1/02 |
主分类号 |
C12N5/071 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|