| 摘要 |
PROBLEM TO BE SOLVED: To provide improved transdermal-delivery devices that are effective for preventing abuse yet useful for delivering a therapeutic agent, such as an opioid or a pharmaceutically acceptable salt thereof.SOLUTION: The invention relates to a tamper-resistant transdermal-delivery comprising an analgesically effective amount of an opioid, or a pharmaceutically acceptable salt thereof, and an acyl opioid antagonist, or a pharmaceutically acceptable salt thereof, in an amount sufficient to inhibit the euphoric effect of the opioid, or pharmaceutically acceptable salt thereof. The transdermal-delivery device allows an analgesically effective amount of the opioid, or a pharmaceutically acceptable salt thereof, to be transdermally administered to a patient. The invention includes a step of contacting the skin of a patient in need of the treatment or prevention with the transdermal-delivery device for an amount of time sufficient to treat or prevent pain. The opioid is oxycodone or the like, and the acyl opioid antagonist is 3-(p-anisoylnaltrexone) or the like. |
