| 摘要 |
The invention relates to biologically active nucleotide molecules for selectively killing off cells, to the use thereof, and to an application kit. The aim of the invention was to kill off cells in a wide application area in the organism actively, reliably, and as effectively as possible without the aforementioned disadvantages of chemical, physical, biochemical, or molecular biological methods known per se. According to the invention, the biologically active nucleotide molecules (8) are designed, with the nucleotide sequence thereof, to be able to bind to the mRNA (7, 9, 10, 11) of several genes in order to trigger several, in particular a plurality of off-target effects for cell-killing stress situations by means of binding of same, by means of which off-target effects the cell (2) is so massively influenced that the cell dies off or the programmed cell death (apoptosis) is initiated in the cell (2), regardless of the classic use of the molecules to reduce the expression of an individual gene. Said molecules are used in particular to selectively kill off tumor- and virus-infected cells, plant cells, and fungal cells. |
