发明名称 |
Stable IgG4 antibodies |
摘要 |
The present invention relates to stabilized IgG4 antibodies, to methods of producing such antibodies and to uses of such antibodies as a medicament. In a main aspect, the invention relates to a stabilized IgG4 antibody, comprising a heavy chain and a light chain, wherein said heavy chain comprises a human IgG4 constant region having a substitution of the Arg residue at position 409, the Phe residue at position 405 or the Lys residue at position 370. |
申请公布号 |
EP2666787(A1) |
申请公布日期 |
2013.11.27 |
申请号 |
EP20130181032 |
申请日期 |
2008.05.30 |
申请人 |
GENMAB A/S |
发明人 |
VAN DE WINKEL, JAN;VINK, TOM;SCHUURMAN, JANINE;PARREN, PAUL;AALBERSE, ROB;VAN DER NEUT KOLFSCHOTEN, MARIJN |
分类号 |
C07K16/28;A61K47/48;A61K51/10;C07K16/00 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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