Method for NMR measurements using dissolution dynamic nuclear polarization (DNP) with elimination of free radicals

摘要

The invention comprises a method for sample preparation for magnetic resonance measurements using Hyperpolarization by Dissolution Dynamic Nuclear Polarization, comprising:
1.1) preparation of frozen beads of a first kind containing paramagnetic substances in addition to the solute under investigation;
2.1) insertion of the frozen beads into a polarizing magnet;
3.1) creation of enhanced polarization of nuclei in a magnetic field;
4.1) heating of the sample to room temperature;
5.1) transfer of the sample to an MR magnet;
6.1) carrying out an MR measurement; characterized in that the method comprises the additional steps:
1.2) preparation of frozen beads of a second kind containing a reducing agent;
2.2) insertion of the frozen beads of the second kind into the polarization magnet together with the frozen beads of the first kind. By this method longitudinal and transverse relaxation times in NMR are extended and free radicals in hyperpolarized solutions are eliminated.