发明名称 |
CYANINE DYES AND SYNTHESIS METHODS THEREOF |
摘要 |
A cyanine dye having formula (II), wherein R1-R8 are each independently selected from a group consisting of hydrogen, C1-C6 alkyl group, and C0-C4 alkyl group having a hydrophilic substituent thereon. R11 and R12 are chosen to include a free or protected thiol, amine or hydroxyl substituent capable of reacting with a target molecule through a nucleophilic displacement mechanism. The dye is useful in labeling a variety of target molecules. Processes are described for synthesizing suitable heterocyclic and indole derivatives as precursors for the aforementioned cyanine dyes. |
申请公布号 |
CA2335240(C) |
申请公布日期 |
2013.11.26 |
申请号 |
CA20002335240 |
申请日期 |
2000.04.19 |
申请人 |
NEN LIFE SCIENCE PRODUCTS, INC. |
发明人 |
RANDALL, MALCOLM HARRY;BUZBY, PHILIP RICHARD;ERICKSON, THOMAS JOSEPH;TROMETER, JOSEPH DAVID;MILLER, JOSEPH JOHN JR.;AHERN, DAVID GEORGE;BOBROW, MARK N. |
分类号 |
C07D209/02;G01N33/533;A61K49/00;C07D209/08;C07D235/04;C07D241/36;C07D263/62;C07D265/02;C07D265/36;C07D277/60;C07D277/62;C07D279/16;C07D401/00;C07D403/02;C07D413/00;C07D417/00;C07D498/02;C09B23/00;C09K11/06 |
主分类号 |
C07D209/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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