| 摘要 |
The invention relates to cyclic bioisosteres of derivatives of a purine system having a general structural formula where R=Li, Na, K, R1=-H, -NH2, -Br, -Cl, -OH, -COOH, B=-N=, -CH=, Z=-CH=, -N=, A=-N= at B=-N=, Z=-CH-, A=-CH= at B=-N=, Z=-CH-, A=-CH= at B=-N=, Z=-N=, A=-CH= at B=-CH=, Z=-CH=, A=-CH= at B=-CH=, Z=-N=, and their pharmacologically acceptable salts having a normalizing effect on endocellular processes, in particular, it is capable eliminating endocellular metabolic acidosis and capable of binding excessively formed free radicals, in particular, free-radical forms of oxygen, capable of normalizing the nitrergic mechanisms of the cells, and also capable of interreacting with adenosine-sensitive receptors on the membrane of non-nuclear cells and in nuclei-containing cells to decrease the aggregation of thrombocytes. The compounds according to the invention have hepatoprotective effect and can be used for producing pharmaceutical compositions on their base.
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