Evaluation/screening method for diseases associated with D-amino acid utilizing DAO1-/-mouse

摘要

Disclosed is an evaluation method which can rapidly discriminate a Dao-/- homozygote from a large number of animals produced in a mating experiment between a DAO enzyme deficient mouse and other disease model mice, to rapidly perform a quantitative measurement of the D-amino acids contained in a large number of samples. The invention provides a method for evaluating the effect of a test condition on a mouse tissue, or cultured tissue cells derived from the tissue. The method comprises the steps of: providing a Dao1-/- mouse or the like; exposing the tissue from the Dao1-/- mouse or the like, to the test condition; and analyzing the effect of exposing the tissue from the Dao1-/- mouse or the like, to the test condition.