| 发明名称 |
BI-AND POLYCYCLIC SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINE DERIVATIVES AS RHO KINASE INHIBITORS |
| 摘要 |
The invention relates to bi- and polycyclic substituted isoquinoline and isoquinolinones of the formula (I) wherein R1 to R12 are as defined in the application useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds. |
| 申请公布号 |
PT2303845(E) |
申请公布日期 |
2013.11.25 |
| 申请号 |
PT20090768941T |
申请日期 |
2009.06.18 |
| 申请人 |
SANOFI |
发明人 |
OLIVER PLETTENBURG;KATRIN LORENZ;SANDRINE BISCARRAT;OLIVIER DUCLOS;MATTHIAS LOEHN |
| 分类号 |
C07D217/24;A61K31/472;A61P9/00;A61P25/00;A61P27/00;A61P37/00;C07D493/08;C07D495/08 |
主分类号 |
C07D217/24 |
| 代理机构 |
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代理人 |
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| 主权项 |
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