| 发明名称 |
Methods and Compositions for the Production of Orthogonal tRNA-Aminoacyl tRNA Synthetase Pairs |
| 摘要 |
This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
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| 申请公布号 |
US2013309720(A1) |
申请公布日期 |
2013.11.21 |
| 申请号 |
US201213475792 |
申请日期 |
2012.05.18 |
| 申请人 |
SCHULTZ PETER G.;WANG LEI;ANDERSON JOHN CHRISTOPHER;CHIN JASON W.;LIU DAVID R.;MAGLIERY THOMAS J.;MEGGERS ERIC L.;MEHL RYAN AARON;PASTRNAK MIRO;SANTORO STEPHEN WILLIAM;ZHANG ZHIWEN;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
SCHULTZ PETER G.;WANG LEI;ANDERSON JOHN CHRISTOPHER;CHIN JASON W.;LIU DAVID R.;MAGLIERY THOMAS J.;MEGGERS ERIC L.;MEHL RYAN AARON;PASTRNAK MIRO;SANTORO STEPHEN WILLIAM;ZHANG ZHIWEN |
| 分类号 |
C12N15/09;C12P21/00;A61K38/00;A61K38/22;A61P7/00;C07K14/00;C07K14/47;C07K14/505;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/00;C12N15/67;C12P13/00;C12P13/04;C12P13/22;C12P19/26;C12P21/02;C12Q1/02;C12Q1/06 |
主分类号 |
C12N15/09 |
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