发明名称 |
EFFICIENT STERILIZATION OF FISH BY DISRUPTION OF GERM CELL DEVELOPMENT |
摘要 |
Methods of disrupting germ cell migration and development in a fish embryo by inducing targeted expression of Sdf-1 a or Lif and disruption of the Sdf-1 a gradient or a Lif signaling pathway in the fish embryo have been developed. Plasmid constructs containing a gene encoding Sdf-1 a or Lif and a gene encoding a signaling sequence for targeted expression of Sdf-1 a or Lif have been generated. The plasmids will be administered to a fish or a population of fish to reproductively sterilize the population with efficacy of up to 100%. Transgenic fish of this invention are reproductively incompetent of genetically contaminating a wild fish population.
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申请公布号 |
US2013312127(A1) |
申请公布日期 |
2013.11.21 |
申请号 |
US201113982418 |
申请日期 |
2011.12.02 |
申请人 |
WONG TEN-TSAO;COLLODI PAUL;PURDUE RESEARCH FOUNDATION |
发明人 |
WONG TEN-TSAO;COLLODI PAUL |
分类号 |
C12N15/85 |
主分类号 |
C12N15/85 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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