POLYPEPTIDE LOADED POCA NANOPARTICLES FOR ORAL ADMINISTRATION

摘要

The disclosure relates to nanoparticles comprising poly(octylcyanoacrylate) for oral administration of a biologically active polypeptide, in particular a metabolic peptide, such as exendin-4. Also disclosed are methods of producing such nanoparticles, pharmaceutical compositions comprising such nanoparticles and methods of treating metabolic disorders, such as obesity, using such nanoparticles.