发明名称 |
USES OF ANTAGONISTS OF HYALURONAN SIGNALING |
摘要 |
Described herein is the finding that hyaluronan antagonists that inhibit hyaluronan signaling are capable of inhibiting airway inflammation and airway hyperresponsiveness (AHR). The present disclosure provides a method of preventing or reducing AHR in a subject suffering from or at risk for AHR by administering a hyaluronan antagonist. Also provided is a method of treating an airway disease or disorder in a subject by administering a hyaluronan antagonist. Hyaluronan antagonists include, for example, heparosan and hyaluronan oligosaccharides (oHAs). In some embodiments, the hyaluronan antagonist is administered locally to the airway, such as with an inhaler or nebulizer. |
申请公布号 |
CA2872569(A1) |
申请公布日期 |
2013.11.21 |
申请号 |
CA20132872569 |
申请日期 |
2013.03.08 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPTARTMENT OF HEALTH & HUMAN SERVICES;DUKE UNIVERSITY;MUSIC FOUNDATION FOR RESEARCH DEVELOPMENT;THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL |
发明人 |
GARANTZIOTIS, STAVROS;HOLLINGSWORTH, JOHN W.;TOOLE, BRYAN P.;LIU, JIAN |
分类号 |
A61K31/727;A61K31/70;A61K31/728;A61K39/35 |
主分类号 |
A61K31/727 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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