发明名称 ANTI-RANTES ANTIBODIES AND METHODS OF USE THEREOF
摘要 PROBLEM TO BE SOLVED: To provide anti-rantes antibodies and to provide methods of use thereof.SOLUTION: The invention relates to fully human monoclonal antibodies, and fragments thereof, that bind to the chemokine Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES, CCL5), thereby modulating the interaction between RANTES and one or more of its receptors, such as, e.g., CCR1, CCR3, CCR4 and CCR5, and/or modulating the biological activities of RANTES. The invention also relates to the use of these or optional anti-RANTES antibodies in the prevention or treatment of immune-related disorders and in the amelioration of one or more symptoms associated with an immune-related disorder.
申请公布号 JP2013234204(A) 申请公布日期 2013.11.21
申请号 JP20130174442 申请日期 2013.08.26
申请人 NOVIMMUNE SA 发明人 FISCHER NICOLAS;KOSCO-VILBOIS MARIE;MACH FRANCOIS
分类号 C07K16/18;A61K39/395;A61K45/00;A61P1/04;A61P1/10;A61P1/12;A61P1/14;A61P7/06;A61P9/08;A61P9/10;A61P11/00;A61P17/06;A61P19/02;A61P29/00;A61P37/02;C12N15/09 主分类号 C07K16/18
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