COMPOSITIONS AND METHODS FOR MODULATING GENE EXPRESSION
摘要
Aspects of the invention provide methods for selecting a candidate oligonucleotide for activating expression of a target gene. Further aspects of the invention provide methods of selecting a set of oligonucleotides that is enriched in oligonucleotides that activate expression of a target gene. Further aspects provide single stranded oligonucleotides that modulate gene expression and compositions and kits comprising the same. Methods for modulating gene expression using the single stranded oligonucleotides are also provided.
申请公布号
WO2013173652(A1)
申请公布日期
2013.11.21
申请号
WO2013US41461
申请日期
2013.05.16
申请人
RANA THERAPEUTICS, INC.;THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL
发明人
KRIEG, ARTHUR, M.;SUBRAMANIAN, ROMESH;MCSWIGGEN, JAMES;LEE, JEANNIE, T.