发明名称 Small-molecule modulators of Trp-p8 activity
摘要 Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.
申请公布号 AU2007215015(B2) 申请公布日期 2013.11.21
申请号 AU20070215015 申请日期 2007.02.15
申请人 DENDREON CORPORATION 发明人 DUNCAN, DAVID F.;MORENO, OFIR;NATARAJAN, SATEESH
分类号 C07C233/60;A61K31/12 主分类号 C07C233/60
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