发明名称 |
Nuclease-Mediated Targeting With Large Targeting Vectors |
摘要 |
Compositions and methods are provided for making one or more targeted genetic modifications at a target genomic locus by employing homologous recombination facilitated by single or double-strand break at or near the target genomic locus. Compositions and methods for promoting efficiency of homologous recombination between an LTVEC and a target genomic locus in prokaryotic or eukaryotic cells using engineered nucleases are also provided.
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申请公布号 |
US2013309670(A1) |
申请公布日期 |
2013.11.21 |
申请号 |
US201313870280 |
申请日期 |
2013.04.25 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
FRENDEWEY DAVID;AUERBACH WOJTEK;VALENZUELA DAVID M.;YANCOPOULOS GEORGE D. |
分类号 |
C12N15/85 |
主分类号 |
C12N15/85 |
代理机构 |
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代理人 |
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地址 |
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