发明名称 |
COMBINATION OF CD37 ANTIBODIES WITH ICE |
摘要 |
The present invention relates to immunotherapies that are based on depletion of CD37-positive cells such as B-cells. The present invention provides methods for reduction of CD37-positive cells such as B-cells in an individual/patient using a combination of CD37 antibody/antibodies and ICE. The combination of CD37 antibodies and ICE is shown to have improved anti-tumor efficacy compared to single agent treatment. The application further provides materials and methods for treatment of diseases involving aberrant B-cell activity.
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申请公布号 |
US2013309225(A1) |
申请公布日期 |
2013.11.21 |
申请号 |
US201313894743 |
申请日期 |
2013.05.15 |
申请人 |
HEIDER KARL-HEINZ;BAUM ANKE;RUSSELL CHARLOTTE ASTRID;BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
HEIDER KARL-HEINZ;BAUM ANKE;RUSSELL CHARLOTTE ASTRID |
分类号 |
A61K39/395;A61K31/555;A61K31/661;A61K31/7048 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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