发明名称 |
LINGO-2 ANTAGONISTS FOR TREATMENT OF CONDITIONS INVOLVING MOTOR NEURONS |
摘要 |
<p>The invention provides methods of treating diseases, disorders or injuries involving motor neuron survival and axonal growth, including amylotrophic lateral sclerosis, by the administration of a LINGO-2 antagonist. An exemplary method for promoting survival of a motor neuron, comprising contacting said motor neuron with an effective amount of a composition comprising a LINGO-2 antagonist selected from the group consisting of: (i) a soluble LINGO-2 polypeptide; (ii) a LINGO-2 antibody or antigen-binding fragment thereof; (iii) a LINGO-2 antagonist polynucleotide; (iv) a LINGO-2 aptamer; and (v) a combination of two or more of said LINGO-2 antagonists.</p> |
申请公布号 |
CA2873623(A1) |
申请公布日期 |
2013.11.21 |
申请号 |
CA20132873623 |
申请日期 |
2013.05.14 |
申请人 |
BIOGEN IDEC MA INC. |
发明人 |
MI, SHA;PEPINSKY, R. BLAKE |
分类号 |
C12N15/12;A61K39/395;A61K47/48;C07K14/47;C07K16/18;C07K17/08;C12N15/13;C12N15/86 |
主分类号 |
C12N15/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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