发明名称 |
METHOD FOR DETERMINING IF A SUBJECT HAS AN INCREASED LIKELIHOOD OF HIGH GRADE DYSPLASIA OR ESOPHAGEAL ADENOCARCINOMA |
摘要 |
The invention related to a method for determining if a subject has an increased likelihood of high grade dysplasia (HGD) or esophagal adenocarcinoma (EC), the method comprising; a) providing a sample from an AFI patch of said subject's oesophagus b) assaying said sample for (i) aneuploidy, and (ii) abnormal p53, and (iii) abnormal Cyclin A c) wherein if said sample shows the presence of at least two of (i), (ii) and (iii), then said subject is determined as having an increased likelihood of high grade dysplasia (HGD) or esophagal adenocarcinoma (EC). The invention also relates to certain methods of medical treatment. |
申请公布号 |
WO2013171508(A1) |
申请公布日期 |
2013.11.21 |
申请号 |
WO2013GB51285 |
申请日期 |
2013.05.17 |
申请人 |
MEDICAL RESEARCH COUNCIL;THE UNIVERSITY OF CAMBRIDGE |
发明人 |
DI PIETRO, MASSIMILIANO;FITZGERALD, REBECCA;LIU, XINXUE |
分类号 |
C12Q1/68;G01N33/50 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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地址 |
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