RILPIVIRINE HYDROCHLORIDE ALCOHOLATE POLYMORPH AND PREPARATION METHOD THEREOF

摘要

A rilpivirine hydrochloride alcoholate polymorph and a preparation method thereof. Specifically, disclosed are three rilpivirine hydrochloride alcoholate polymorphs and preparation methods thereof as follows: a rilpivirine hydrochloride methylate E-type polymorph, a rilpivirine hydrochloride ethylate F-type polymorph, and a rilpivirine hydrochloride n-propylate G-type polymorph. Further disclosed is a new preparation method of a rilpivirine hydrochloride A-type or C-type polymorph.