发明名称 |
BENZAMIDE DERIVATIVES FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1 |
摘要 |
The present invention relates to compounds of formula (I): in which Y, Y, R, R 2, R 3 and R 4 are defined in the Summary of the Invention; capable of inhibiting the tyrosine kinase enzymatic activity of the Abelson protein (ABL1), the Abelson- related protein (ABL2) and related chimeric proteins, in particular BCR-ABL1. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers. |
申请公布号 |
CA2871715(A1) |
申请公布日期 |
2013.11.21 |
申请号 |
CA20132871715 |
申请日期 |
2013.05.09 |
申请人 |
NOVARTIS AG |
发明人 |
FURET, PASCAL;GROTZFELD, ROBERT MARTIN;JONES, DARRYL BRYNLEY;MANLEY, PAUL;MARZINZIK, ANDREAS;PELLE, XAVIER FRANCOIS ANDRE;SALEM, BAHAA;SCHOEPFER, JOSEPH;JAHNKE, WOLFGANG |
分类号 |
C07D401/04;A61K31/4439;A61K31/444;A61K31/496;A61K31/5377;A61P31/00;C07D401/14;C07D403/10;C07D405/14;C07D409/14;C07D413/14;C07D417/10;C07D417/14 |
主分类号 |
C07D401/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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