发明名称 |
Recombinant immunotoxin targeting mesothelin |
摘要 |
Mesothelin is a differentiation antigen present on the surface of ovarian cancers, mesotheliomas and several other types of human cancers. Because among normal tissues, mesothelin is only present on mesothelial cells, it represents a good target for antibody mediated delivery of cytotoxic agents. The present invention is directed to improved recombinant immunotoxins comprising anti-mesothelin antibodies, including Fv molecules with particularly high affinity for mesothelin, and a Pseudomonas Exotoxin moiety which has been modified to reduce its immunogenicity and protease sensitivity and providing a better cytotoxicity for cells which expresss mesothelin. The RITs are well-suited for the treatment of cancers of the ovary, stomach, squamous cells, mesotheliomas and other malignant cells expressing mesothelin. |
申请公布号 |
AU2012253896(A1) |
申请公布日期 |
2013.11.21 |
申请号 |
AU20120253896 |
申请日期 |
2012.05.04 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA ASREPRESENTED BY THE SECRETARY OF THE DEPARTMENT OFHEALTH AND HUMAN SERVICES |
发明人 |
PASTAN, IRA H.;WELDON, JOHN;BEERS, RICHARD |
分类号 |
C07K14/21;A61K39/00;C07K16/30 |
主分类号 |
C07K14/21 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|