NUCLEAR MAGNETIC RESONANCE APPARATUS, SYSTEMS, AND METHODS

摘要

In one aspect, the disclosure relates to a nuclear magnetic resonance (NMR) transceiver including: (a) a variable-frequency electromagnetic (EM) signal generator with (i) a frequency input and (ii) an EM signal output; (b) an electronic frequency controller including (i) a frequency output coupled to the frequency input of the variable-frequency EM signal generator, (ii) an intermediate frequency set-point input, and (iii) an intermediate frequency measurement input; (c) an NMR transmission probe with an EM signal input coupled to the EM signal output of the variable-frequency EM signal generator; (d) an NMR receiving probe with an EM signal output; and (e) an electronic mixer with (i) a first input coupled to the EM signal output of the NMR receiving probe, (ii) a second input coupled to the EM signal output of the variable-frequency EM signal generator, and (iii) a mixed EM signal output coupled to the frequency measurement input of the frequency controller. The NMR transceiver can further include a power amplifier incorporating a variable-gain feedback controller to control the power applied to the NMR transmission probe. The NMR transceiver and related apparatus can be used to detect biological or chemical analytes labeled with magnetic nanoparticle biomarkers.