发明名称 COMPOUNDS AND METHODS FOR DETECTION OF ENZYMES THAT REMOVE SUCCINYL GROUPS FROM EPSILON-AMINO LYSINE MOIETIES
摘要 Provided is a compound that comprises the structure: where SIG is a signaling molecule and R3 is a formyl, a succinyl, a methyl succinyl, or a myristoyl. Also provided is a kit is provided that comprises the above compound, with instructions for determining the presence of the enzyme. Additionally, a method is provided for determining whether a sample has an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an &egr;-amino of a lysine. Also provided is a method of determining whether a molecule inhibits an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an &egr;-amino of a lysine.
申请公布号 EP2663648(A1) 申请公布日期 2013.11.20
申请号 EP20120706346 申请日期 2012.01.03
申请人 ENZO LIFE SCIENCES, INC. 发明人 HOWITZ, KONRAD T.;ZHANG, ZHONGDA;KISIELEWSKI, ANNE;DALE, ELIZABETH;PATTON, WAYNE FORREST
分类号 C07D311/16;C07D493/10;C12Q1/34 主分类号 C07D311/16
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