发明名称 |
DIFFERENTIAL INTERFERENCE CONTRAST SERIAL TIME ENCODED AMPLIFIED MICROSCOPY |
摘要 |
We describe methods and apparatus for high-speed high-contrast imaging one-, two- and three-dimensional imaging enabled by differential interference contrast time encoded amplified microscopy of transparent media without the need for chemical staining, that are suitable for a broad range of applications from semiconductor process monitoring to blood screening. Our methods and apparatus build on a unique combination of serial time-encoded amplified microscopy (STEAM) and differential interference contrast (DIC) microscopy. These methods and apparatus are ideally suited for identification of rare diseased cells in a large population of healthy cells and have the potential to revolutionize blood analysis and pathology including identification of cancer cells, such as Circulating Tumor Cells (CTC) in early stage disease.
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申请公布号 |
EP2583053(A4) |
申请公布日期 |
2013.11.20 |
申请号 |
EP20110827118 |
申请日期 |
2011.06.21 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
JALALI, BAHRAM;MOTAFAKKER-FARD, ALI |
分类号 |
G01B9/02;G01B11/24;G01J1/04;G02B21/00;G02B21/14;H04N5/14 |
主分类号 |
G01B9/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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