发明名称 |
EXPORT AND MODIFICATION OF (POLY)PEPTIDES IN THE LANTIBIOTIC WAY |
摘要 |
The invention includes a method for harvesting a polypeptide produced by a host cell, wherein the polypeptide has not undergone intracellular posttranslational modification, such as dehydration of a serine or a threonine, and/or thioether bridge formation. The invention also includes a method for producing thioether-containing peptides and dehydroalanine/dehydrobutyrine-containing.peptides, wherein thioether rings may be formed extracellularly. |
申请公布号 |
EP1507798(B1) |
申请公布日期 |
2013.11.20 |
申请号 |
EP20030733622 |
申请日期 |
2003.05.26 |
申请人 |
LANTHIOPEP B.V. |
发明人 |
MOLL, GERT NIKOLAAS;LEENHOUTS, CORNELIS JOHANNES;KUIPERS, OSCAR PAUL;DRIESSEN, ARNOLD JACOB MATHIEU |
分类号 |
C07K14/315;A61K38/14;C07K9/00;C12N5/06;C12P21/02 |
主分类号 |
C07K14/315 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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