发明名称 |
METHOD FOR ENHANCING ENGRAFTMENT OF HAEMATOPOETIC STEM CELLS |
摘要 |
The present invention provides a novel method for enhancing engraftment of haematopoetic stem cells by an ex-vivo pretreatment comprising the steps of obtaining a sample containing haematopoetic stem cells and admixing a prostacyclin analogue to obtain a mixture, incubating said mixture for a period of time sufficient to stimulate G alphas-signalling in said cells and optionally and isolating said stimulated cells. Further, a composition comprising a prostacyclin analogue for use in the treatment of individuals undergoing haematopoetic stem cell transplantation is provided. |
申请公布号 |
EP2663313(A1) |
申请公布日期 |
2013.11.20 |
申请号 |
EP20120700137 |
申请日期 |
2012.01.13 |
申请人 |
SCIPHARM SARL |
发明人 |
FREISSMUTH, MICHAEL;ZEBEDIN-BRANDL, EVA-MARIA;BERGMAYR, CHRISTIAN;HUSSAIN, FILZA |
分类号 |
A61K31/5585;A61K35/28;C12N5/078 |
主分类号 |
A61K31/5585 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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