POLYNUCLEOTIDE SEQUENCE CODING STRUCTURED PERTACTIN PROTEIN; VECTOR INCLUDING SUCH SEQUENCE; AND VACCINE COMPOSITIONS CONTAINING PERTACTIN PROTEIN OR VECTOR

摘要

FIELD: biotechnologies.SUBSTANCE: inventions refer to polynucleotide sequence coding the structured pertactin protein (Prn); a vector including such a sequence and compositions containing protein or vector. The characterised polynucleotide sequence codes 300 first amino acids that are the closest to N-end of this type of natural mature Prn (PrnX300), and amino-acid sequence including 620 last amino acids that are the closest to C-end of this type of natural mature Prn (PrnY620) so that structured pertactin PrnX300-PrnY620 of Bordetella class is obtained. Structured molecules Prn include polymorphisms of different B. Pertussis strains and cause immune responses with increased protective ability and opsonophagocytic activity, which exceed the corresponding properties of the preceding vaccines.EFFECT: protein obtained as per the presented invention can be used in medicine and veterinary as a component of antibacterial vaccines against Bordetella pertusis.12 cl, 3 dwg, 2 tbl, 4 ex